Remote synchronous delivery for interior design education: The shift toward innovative paradigms in design teaching approaches

In the uncertain COVID-19 situation, professionals working in education development and learning strategies start to wonder why the situation seems strange or even tough. Institutions got involved, somehow, in online teaching delivery. Most post-secondary institutions worldwide began to use virtual learning or remote synchronous delivery (RSD) as the most applicable method to keep a connection with students in a social-distancing situation. It might be too early to rush to drive solutions or summarize conclusions. The key point is to reach for expressive questions that describe and evaluate the situation in interior design education - an advanced step in the diagnosis of the current situation. This chapter investigates how the current pandemic situation affected teaching methods in the Bachelor of Interior Design (BID) program at University X. The chapter explores remote synchronous delivery in this program with a focus on three core interior design streams: studio, visual communication, and software and technology. As a response to crisis situations, the chapter begins to answer these questions: How did remote synchronous delivery affect interior design education? How can we be prepared for advanced teaching approaches? Will this pandemic lead to innovative approaches in interior design teaching pedagogy? © Springer Nature Switzerland AG 2021. All rights reserved.

Change in departure time for a train trip to avoid crowding during the COVID-19 pandemic: A latent class study in the Netherlands

The energy-efficient plate heat exchanger (PHE) and refrigerant R1234yf, which has a low global warming potential (GWP), can be used to realize an energy efficient heat pump (HP) system for electric vehicles (EV), extending their driving range. Therefore, the characteristics of R1234yf in an offset-fin strip (OSF) flowstructured PHE are critical for heat-exchanger design. This study investigates the condensation heat transfer coefficient (C-HTC) and two-phase frictional pressure drop (2P-FPD) of R1234yf during condensation in an OSF flow-structured PHE under various operating conditions. First, a modified Wilson plot method was used to determine the multiplier (C) and Reynolds number exponential (n) for the coolant side as -0.426 and 0.494, respectively. When the heat flux (q), average vapor quality (xa), and mass flux (G) increased, the C-HTC increased, whereas it decreased with saturation temperature (Tsat). Despite the force-convective condensation flow regime, the C-HTC increment was minimal with G at lower xa owing to the lesser significance of the shear effect. Additionally, the 2P-FPD was unaffected by q but increased considerably with an increase in xa and G and a decrease in Tsat. Based on the current experimental database, empirical correlations for forecasting friction factor and Nusselt number were developed with a 91% predictability.

Remote Synchronous Delivery (RSD): Lessons learned from teaching during COVID-19

The start of a new decade, 2020, was filled with many global issues but none as profound as the COVID-19 pandemic. North America watched the crisis unfold half the world away with little inkling that in a matter of weeks it would impact how we live, work, and educate. This chapter focuses on how the COVID-19 pandemic affected the way undergraduate programing is delivered at a private for-profit university. The new adapted model mimics the face-to-face classroom experience via video-conferencing live online sessions platform. This model is called remote synchronous delivery (RSD). This narrative vignette describes the RSD model in hopes of making sense and learning from this rapid development of a third space. The vignette considers the impact of the RSD model on students, faculty, curriculum, and the live online sessions platform. Evaluating the implications of RSD creates the space for reflection of other delivery models such as online courses, hybrid, and even the traditional face-to-face classroom experience. The chapter concludes with lessons learned and future implications. © Springer Nature Switzerland AG 2021. All rights reserved.

The state of health in Pakistan and its provinces and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding health trends and estimating the burden of disease at the national and subnational levels helps policy makers track progress and identify disparities in overall health performance. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides comprehensive estimates for Pakistan. Comparison of health indicators since 1990 provides valuable insights about Pakistan's ability to strengthen its health-care system, reduce inequalities, improve female and child health outcomes, achieve universal health coverage, and meet the UN Sustainable Development Goals. We present estimates of the burden of disease, injuries, and risk factors for Pakistan provinces and territories from 1990 to 2019 based on GBD 2019 to improve health and health outcomes in the country. Methods We used methods and data inputs from GBD 2019 to estimate socio-demographic index, total fertility rate, cause-specific deaths, years of life lost, years lived with disability, disability-adjusted life-years, healthy life expectancy, and risk factors for 286 causes of death and 369 causes of non-fatal health loss in Pakistan and its four provinces and three territories from 1990 to 2019. To generate estimates for Pakistan at the national and subnational levels, we used 68 location-years of data to estimate Pakistan-specific demographic indicators, 316 location-years of data for Pakistan-specific causes of death, 579 location-years of data for Pakistan-specific non-fatal outcomes, 296 location-years of data for Pakistan-specific risk factors, and 3089 location-years of data for Pakistan-specific covariates. Findings Life expectancy for both sexes in Pakistan increased nationally from 61 center dot 1 (95% uncertainty interval [UI] 60 center dot 0-62 center dot 1) years in 1990 to 65 center dot 9 (63 center dot 8-67 center dot 8) years in 2019;however, these gains were not uniform across the provinces and federal territories. Pakistan saw a narrowing of the difference in healthy life expectancy between the sexes from 1990 to 2019, as health gains for women occurred at faster rates than for men. For women, life expectancy increased by 8 center dot 2% (95% UI 6middot3-13middot8) between 1990 and 2019, whereas the male life expectancy increased by 7 center dot 6% (3 center dot 5-11 center dot 8). Neonatal disorders, followed by ischaemic heart disease, stroke, diarrhoeal diseases, and lower respiratory infections were the leading causes of all-age premature mortality in 2019. Child and maternal malnutrition, air pollution, high systolic blood pressure, dietary risks, and tobacco consumption were the leading all-age risk factors for death and disability-adjusted life-years at the national level in 2019. Five non-communicable diseases-ischaemic heart disease, stroke, congenital defects, cirrhosis, and chronic kidney disease-were among the ten leading causes of years of life lost in Pakistan. Burden varied by socio-demographic index. Notably, Balochistan and Khyber Pakhtunkhwa had the lowest observed gains in life expectancy. Dietary iron deficiency was the leading cause of years lived with disability for both men and women in 1990 and 2019. Low birthweight and short gestation and particulate matter pollution were the leading contributors to overall disease burden in both 1990 and 2019 despite moderate improvements, with a 23 center dot 5% (95% UI 3 center dot 8-39 center dot 2) and 27 center dot 6% (14 center dot 3-38 center dot 6) reduction in age-standardised attributable DALY rates during the study period. Interpretation Our study shows that progress has been made on reducing Pakistan's disease burden since 1990, but geographical, age, and sex disparities persist. Equitable investment in the health system, as well as the prioritisation of high-impact policy interventions and programmes, are needed to save lives and improve health outcomes. Pakistan is facing several domestic and foreign challenges-the Taliban's return to power in Afghanistan, political turmoil, catastrophic flooding, the COVID-19 pandemic-that will shape the trajectory of the country's health and development. Pakistan must address the burden of infectious disease and curb rising rates of non-communicable diseases. Prioritising these three areas will enhance Pakistan's ability to achieve universal health coverage, meet its Sustainable Development Goals, and improve the overall health outcomes.

Diet quality as a mediator in the relationship between perceived stress and depression among family caregivers of patients with chronic illness in Saudi Arabia.

OBJECTIVE: The purpose of this research was to examine the correlation between caregivers' perceived stress and depression and the mediating role of diet in this relationship. METHODS: A cross-sectional survey was performed from January to August 2022 in the Kingdom of Saudi Arabia. Utilizing the Stress Scale, the Anxiety and Depression Scale, the Health Promoting Lifestyle Profile-II questionnaire, and the Patient Health Questionnaire-9, researchers assessed levels of perceived stress, diet quality, and depression. A bootstrap approach and the SPSS PROCESS macro were used to assess the importance of the mediation effect. The target population was family caregivers of patients with chronic illness at Medical City in Saudi Arabia. Researchers surveyed a convenience sample of 127 patients, with 119 providing complete data for a response rate of 93.7%. A significant correlation was found between depression and perceived stress (ß = 0.438, p < 0.001). Diet quality mediated the relationship between depression and perceived stress (ß = 0.187, p = 0.018). The importance of the indirect effect of perceived stress through diet quality was supported by the nonparametric bootstrapping method (95% bootstrap CI = 0.010, 0.080). The indirect effect of diet quality explained 15.8% of the overall variation in depression. CONCLUSIONS: These findings help to clarify the mediating effects of diet quality on the relationship between perceived stress and depression.

Moving to Medical Treatment for COVID-19 Influence on Pediatric Appendicitis: A Meta-Analysis.

Acute appendicitis (AA) is cited as the leading cause of surgical acute abdomen in pediatrics and the most frequent urgent surgical pathology worldwide. For a long time, surgical appendectomy has been effectively used as the first-line treatment for AA. Other conservative management practices, such as the use of antibiotics, have been applied in the treatment of appendicitis. COVID-19 has had a significant impact on the surgical treatment strategies of AA in pediatrics, with many pediatric surgeons having to shift from upfront surgical appendectomy to conservative management involving the use of antibiotics as a treatment strategy. This meta-analysis compares the outcomes between appendectomy and conservative therapy in the management of AA during COVID-19 in pediatrics. Twenty-one articles fully met the inclusion criteria. Articles that were published more than five years ago were excluded from the analysis. Also, articles that included studies on the adult population were excluded. Results from various retrospective studies, prospective clinical controlled trials, correlational studies, and randomized clinical trials were analyzed. This study reveals that the use of antibiotics has been demonstrated to be safe and effective in the treatment of uncomplicated appendicitis. However, antibiotics have been shown to have some complications. Despite this being the case, the studies identified the potential of using antibiotics as a definitive treatment of uncomplicated AA in pediatrics. Further studies are required to evaluate the cost-effectiveness and recurrence of AA of this alternative treatment method.

Factors Linked with an Increased Risk of Death in Patients with Covid-19

Objective: The purpose of this study was to determine the factors that increase a patient's chances of death from COVID-19. Study Design: Retrospective study Place and Duration: Medicine department of Benazir Bhutto Hospital (BBH) and Holy Family Hospital (HFH), Rawalpindi during the period from November 2021 to April 2022. Method(s): Total 142 patients of both genders of confirmed coronavirus disease were included. After receiving informed written consent from each participant, detailed demographic information was obtained. This information included the participant's age, gender, body mass index, and list of co-morbidities. Frequency of mortality and factors that increase a patient's chances of death were recorded. SPSS 24.0 was used to analyze all data. Result(s): We found that 87 (61.3%) cases were males and 55 (38.7%) patients were females. Majority of the patients 53 (37.3%) had age >45 years. 65 (45.8%) patients were smokers. Severity of disease was found in 76 (53.5%) cases. There were 95 (66.9%) patients had hypertension, diabetes mellitus found in 75 (52.8%) cases, cardiovascular disease in 48 (33.8%) cases, pulmonary disease in 40 (28.2%) cases and chronic kidney disease in 34 (23.9%) cases. Among 142 patients, 27 (19.01%) patients were died. Among non-survivals, kidney dysfunction was the most common reason found in 17 cases, followed by cardiovascular and diabetes mellitus. Conclusion(s): We came to the conclusion that clinical risk factors for a fatal consequences associated with coronavirus include chronic chronic conditions, complications, and demographic variables. These risk factors include acute renal injury, diabetes, hypertension, heart disease, male sex, older age, current smoker, and obesity. The findings might be used to future study on the disease as well as its control and prevention. Copyright © 2022 Lahore Medical And Dental College. All rights reserved.

TumerNecrosis in COVID19 and Dibates

Background: The World Health Organization (WHO) and health authorities have devoted significant attention to understanding risk factors for coronavirus disease 19 (COVID-19) and their role in disease outcomes including tumer necrosis factor. In addition, diabetes may lead to lung dysfunction, such as decreased forced expiratory volume and forced vital capacity. Therefore, diabetes could possibly be a risk factor for covid-19. Our study aims to investigate the clinical characteristics of patients with severe covid-19 with diabetes mellitus, and the association of diabetes with the outcome in patients with severe covid-19. Materials and Methods: This study was carried out in a period between November 2021 and March 2022, blood was taken from patients (80) with covid-19. Samples were taken from patients who were present in Al-Zahraa teaching hospital in Iraq. A total of samples were subjected to laboratory examinations including Tumor necrosis factor α using specific ELISA Kit. Result: The result of this observational study was depending on the analysis of data from 80 COVID-19 patients. All selected sociodemographic features, disease indicators, and history of chronic disease were listed as frequencies and percentages. The mean age was 52 years old. The SPO2 for those patients was ranged from 79 to 95% with a mean equal to 90.10 ±3.48. All patients showed elevated CRP value with a mean = 83.52. More than half of the sample (52.5%) were females and near half of the (48.8%) were overweighted when calculate their BMI. The majority (92.5%) mentioned having no family history of diabetes mellitus and 95% of them have no any other diagnosed chronic disease. Near two thirds (67.5%) were prescribed steroid in the treatment regime for their COVID-19 infection. Mean difference of TNF was tested among positive Covid-19 having diabetic status, results showed that.

IMPACT OF THE ONLINE LEARNING TECHNIQUES ON STUDENTS' CUMULATIVE GRADE POINTS

When COVID-19 prevailed, the educational system was shifted to online rather than traditional to facilitate the learning process. This study aimed at exploring the impacts of online learning techniques on the students' Cumulative Grade Point Average (CGPA). A total of 155 randomly selected students currently studying M. Phill education at the University of Agriculture Faisalabad, Pakistan participated in this study. Data were collected through validated, pre-tested and reliable questionnaires. Collected data were analyzed using Statistical Package for Social Sciences (SPSS). Findings unveiled that online learning techniques improved the learning abilities, personality traits and teaching styles as perceived by the respondents which further improved the CGPA of students. Within the effects on learning abilities, enabling students to judicious use of technology, multimedia, observation and clearing the concepts were major improvements which helped students to attain an increase in CGPA. As for as effects on personality traits were concerned, social interaction enhanced communication skills and improvement in understanding, social skills and confidence led the students to get high CGPA. Moreover, online learning improved the teaching styles by integrating video lectures, immediate results assessment and easy access to the technology were key drivers of the increase in CGPA. This study suggested a hybrid educational system at the University of Agriculture Faisalabad for effective learning in students.

Big Data Analysis and Data Visualization to Help Make a Decision - Islamic Banks Case Study

Interest in data of various forms and sizes has risen in recent years, and it has become a defining aspect of modern period. The use of digital transformation strategies and their role in recovering from the consequences of the Corona pandemic, particularly in financial institutions, is the focus of this case study on Islamic banks. This study examines the big data analysis cycle for five Islamic banks’ data in the 2019/2020 era. In addition to following the five steps of the big data analysis cycle and concentrating on the phase of developing a model in order to produce graphical results that can be studied. It will make use of Google Data Studio, which is one of the greatest tools for analyzing large amounts of data. On the other hand, after creating the relevant hypotheses, it will explore possible scenarios and the visuals that result. Finally, there are visualizations and reports that assist decision-makers and investors in evaluating bank performance before to and during the Corona pandemic, making it easier to follow financial performance and conduct of banks. The research also considers the consequences of bank graphical reporting and considers whether hypotheses to help capture all statistical results in visual form are required. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Study Significance of Low Plasma Homocysteine or Hypohomocysteinemia and Some Parameter to Syndrome Associated with COVID-19 in Basrah City, Iraq

The increasing interdependence between the countries of the world has led to an increase in the risks faced by societies in general. The COVID-19 pandemic, for example, has transcended national borders, affecting people regardless of nationality, level of education, income or gender. As for its consequences, it has affected the most vulnerable groups. In this study, we have considered the significance of low plasma homocysteine or hypohomocysteinemia and some parameters of the syndrome associated with COVID-19. Just as an increase in the level of homocysteine in plasma has a negative effect on the heart and blood vessels, its decrease may put the health of those who suffer from it at risk. Homocysteine is known to be the natural mediator of the conversion of methionine to cysteine;hence, the danger, as the latter is necessary for the production of glutathione, taurine and sulphate. In this study, homocysteine and some indicators of COVID-19 syndrome were examined using ELISA kit and other methods. The homocysteine level in the serum of people who recovered from COVID-19 was found to be lower than in normal and healthy people. Thus, it indicates that people who have been cured may suffer from hypohomocystinemia. We also study some parameters, such as ALP, GOT, GPT, Glucose level and HDL, cholesterol. The results showed a significant decrease in the level of GOT enzyme and HDL level. © 2022-IOS Press. All rights reserved.

The first year of a national-access adult Klinefelter's Syndrome multi-disciplinary team (KSMDT) clinic: patient and clinician reported outcomes

Klinefelter's syndrome is the most common chromosomal abnormality seen in men, affecting 1 in 650 men. It is a group of chromosomal disorders with at least one extra X chromosome (47, XXY) occurring due to non-disjunction at the time of gametogenesis. Most adult men are diagnosed at the time of fertility investigations. However, the syndrome has an array of clinical presentations which patients require input from numerous medical specialities during their lifetime. The setting up of a national-access Klinefelter Syndrome multidisciplinary clinic (KSMDT) approach comprising Urology, Endocrinology, Genetics, Reproductive medicine, Radiology, Psychosexual medicine, a specialist pharmacist as well as a patient representative has led to improvements in fertility and long- term management and waiting times. Here we describe the patient-reported outcomes and clinician perspectives of the clinic as it approached its 1st year. Between 2019 and 2020, 72 patients were seen in the adult KS MDT clinic. To assess the quality of care received in the clinic, an 8 -point feedback questionnaire was given to each patient attending the clinic to fill out at the end of the clinic. The form included a space for feedback for each speciality involved. The feedback forms were reviewed by 2 individual researchers and entries were assessed using an adapted Likert scale (0 – 5). Clinicians involved in the clinic were also encouraged to attend and rate the other specialties, the effectiveness of the pre and post clinic MDTs and to describe achievements derived from KSMDT clinic team-working. All the patients (n = 72) took the questionnaire reported that the clinic was beneficial to their understanding of KS & its management and had enough time during consultations. In terms of scoring 86% were very satisfied (score = 5) about genetic consultation compared to 92%, 82%, 82% and 88% in endocrine, fertility, psychosexual and urology consultation, respectively. Key factors influencing these positive results included the presence of an MDT, the access to a patient liaison and knowledge of support groups during the consult, digitized patient information sheets and a cohesive approach between endocrine and fertility teams. Clinician feedback was positive with all members agreeing that the pre and post clinic MDTs allowed effective pinpointing of often missed issues (e.g. hormone induction, social issues). Key milestones for the clinic included the reduction in waiting times by almost 80%, securing funding for costly hormone medication and assisted reproduction, improving sperm retrieval rates (from 11 – 29%) and a thrombo-embolism awareness programme. The overall patient and clinician feedback for the adult KSMDT clinic was uniformly positive, with the multispecialty approach allowing communication with and between all relevant specialities on the same day, avoiding the need to come for multiple separate appointments across different sites (especially relevant during the COVID-19 era). The feedback has also been useful in developing patient information tools such as digital resources and has led to the development of a supportive community group for newly diagnosed KS men. More research is underway to investigate the complex issues affecting KS men long term, after fertility management. Work supported by industry: no. [ FROM AUTHOR] Copyright of Journal of Sexual Medicine is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Effect of telegram videos on anatomy education among 2nd year medical students, University of Khartoum, 2021

Aim: COVID-19 had major effect on the health and medical education. In order to oblige with the social distancing and quarantine, universities shifted to online learning. This study aimed to assess the effect of online education on anatomy DR (dissection room) teaching by the use of telegram software. Method: This was a cross-sectional, prospective interventional study, which was carried out among 2nd year medical students in University of Khartoum. Students undertook initial tests on the heart and anterior abdominal wall modules. Telegram videos, prepared by the author, on the anatomy of the heart and the anterior abdominal wall were distributed to students. Students took a second test after watching the videos. A total number of 41 students attended heart sessions and 40 students attended the anterior abdominal wall sessions were included. Results: The pre-test mean score for the heart and abdomen modules were 4.56 ± 2.335 and 6.15 ± 2.94, respectively. The post-tests means were 9.98±2.877 and 8.95±3.14, respectively. 90% and 75% of the students were satisfied with these videos, respectively. Conclusions: This study revealed that Telegram videos as a method of online teaching had a positive effect on the students' performance, which was evidenced by the significant improvement in student's scores after watching the videos. Additionally, most of the students were satisfied with the videos and give positive feedback.

Data Mining Technique for Prediction System of Heart Disease Using Associative Classifications

In this study, several aspects of the human body have been focused upon. This paper attempts to cast light on pre-and post-pathological conditions, man-machine interactions, human mindset, and ethics of AI. The paper emphasizes the cultural impacts of overeating, profuse drinking, and smoking habits. It uplifts the basic necessity of growing awareness schemes. Patients are seeking treatment in health care centers with the following serious pathological conditions and complications (We exclude the COVID-19 pandemic because it has been adequately publicized by media and press): Heart Attack, Stroke Cancer, Fatty liver & liver cirrhosis. Because of being the leading causes of sudden death prediction of heart attack is very important. Our main focus is to determine the best machine learning method. With optimal parameters, we evaluate the Dataset. Model Accuracy for the heart Attack Machine Learning Model was the highest for the Logistic Regression mode land it was 93.41%. On the contrary, the accuracy for Linear Regression Model was 60.10% which was the least. © 2021 IEEE.

Modular Printed Powered Air Purifying Respirator

At present, the world is undergoing a pandemic spawning from the advent of a new coronavirus outbreak known as COVID-19. As a result, hospital staff, paramedics, first responders, and the general world population have been forced to wear personal protective equipment (PPE) and take special measures to prevent catching the virus. Furthermore, because of this necessity, increasing demand on the PPE supply chain has generated many shortages, especially seen in masks designed to stop the inhalation of COVID-19 particles in the air. This inspired our group to design something that could help make PPE more accessible and affordable for the average person. The proposed is an almost entirely 3D printed design to help keep costs down and make it simplistic, such that anyone with a 3D printer has the potential to duplicate it. We hope that with the design, we can help combat the shortage and keep more people safe from COVID-19. Copyright © 2021 by ASME.

Highly-sensitive and rapid detection of COVID-19 in wastewater: a comprehensive review based on graphene field effect transistor biosensor

The novel Corona Virus Disease 2019 (COVID-19) has been spread from the Wuhan city of China has now affected many countries;it is still circulating worldwide. Consecutive studies of finding the RNA of this virus in sewage systems increase renewed interest about COVID-19 faucal transmission and its pathogenic issue on sanitation and wastewater systems. Municipal wastewater is typically remarked as one of the major end routes of different types of emerging contaminants such as pharmaceuticals, endocrine disruptors, antibiotics, micro plastics, pesticide and heavy metal residues associated with antimicrobial resistance. Currently all available, antibodies based and molecular base testing have some limitations for this purpose: whole coronavirus particles instead of pure antigen proteins need to be tested in a short time and take control of the pandemic of COVID-19. The current study helped in understanding, concept and demonstrated the potential of graphene Field Effect Transistor (FET) technology for sensitive and rapid detection of corona viruses. Therefore, extra trustworthy, quick response, economical and broadly accessible analytical devices or diagnostic approaches are crucially required. We have critically reviewed and argued the biomarkers and indicators used for COVID-19 diagnostics or SARS-CoV-2 detection. In this regard, ultrasensitive graphene FET biosensors are powerful tools in early diagnosis of COVID-19 infection via targeting virus S1 protein to assess the clinical progress and offer awareness on severity and critical trends of infection.

Safety and Efficacy of Cusatuzumab in Combination with Venetoclax and Azacitidine (CVA) in Patients with Previously Untreated Acute Myeloid Leukemia (AML) Who Are Not Eligible for Intensive Chemotherapy;An Open-Label, Multicenter, Phase 1b Study

Background: Acute myeloid leukemia (AML) is driven by aberrant leukemic stem cells (LSCs) that initiate and sustain malignancy. To circumvent resistance to therapy, combination therapies with additive mechanisms of action are needed. CD70, a tumor necrosis factor receptor ligand, and its receptor CD27 are expressed on LSCs and AML blasts, but not on hematopoietic stem cells. Cusatuzumab, a high-affinity humanized monoclonal anti-CD70 antibody, kills CD70-expressing cells by Fc domain-mediated effector functions and is a potent inhibitor of CD70-CD27 signaling. Here we report initial results of a study of cusatuzumab in combination with the current standard of care therapy, venetoclax plus azacitidine (CVA), in patients with untreated AML (de novo or secondary) ineligible for intensive chemotherapy due to age ≥75 years or medical comorbidities. Methods: The primary objective of this open label, multicenter, phase 1b study was to assess safety and tolerability of CVA. Key secondary objectives included response rate per ELN 2017 criteria and time to response. Patients received cusatuzumab 10 or 20 mg/kg IV on Day 3 and Day 17, a 3-day ramp-up of venetoclax (100, 200, and 400 mg PO) followed by 400 mg daily dosing, and azacitidine 75 mg/m 2 SC or IV on Days 1-7 of each 28-day cycle. Results: Based on data through Jul 9, 2021, 44 patients enrolled with median age 75 years (range 32-89), 36.4% had secondary AML, 40.9% had an ECOG performance status of 2, and ELN risk was favorable, intermediate and adverse in 18.2%, 20.5% and 61.4%, respectively. All patients received 20 mg/kg cusatuzumab except for 3 patients who received a starting dose of 10 mg/kg with the option to escalate to 20 mg/kg. Of these 3 patients, 1 escalated to 20 mg/kg. At a median follow-up of 29.1 weeks, the median number of treatment cycles was 4.0 (range 1.0-11.0). Grade 3 or above TEAEs were reported in 97.7% of patients;the most common (reported in ≥10%) were neutropenia (68.2%), thrombocytopenia (65.9%), febrile neutropenia (36.4%), anemia (34.1%), leukopenia (29.5%), sepsis (27.3%), and lymphopenia (15.9%). Treatment-emergent serious adverse events (SAEs) were reported in 75% of patients;the most common (reported in at least ≥5%) were febrile neutropenia (27.3%), sepsis (22.7%), COVID-19 (6.8%), and thrombocytopenia (6.8%). Treatment-emergent SAEs of grade ≥3 were reported in 72.7% of the patients. Infusion-related reactions (IRRs) were reported for 11.4% of patients with 2.3% at grade ≥3. Six (13.6%) patients discontinued treatment due to AEs, and 5 (11.4%) TEAEs resulted in death. The mortality rate within 30 days from start of treatment was 4.5%. Table 1 summarizes best response to study treatment. In the intent-to-treat analysis set (n=44) complete remission (CR) rate was 45.5%, while CR + CR with partial hematologic recovery (CRh) + CR with incomplete hematologic recovery (CRi) was 77.3%;MLFS was observed in 11.4% of patients. Of 34 responders (defined as CR, CRi or CRh), 47% were MRD negative by flow cytometry at or after achievement of response. Median time to first response for patients who achieved CR, CRh or CRi was 4.21 (3.0-25.0) weeks. Best response rates in the post-hoc response evaluable analysis set (n=42) that excluded two patients who died before the first disease evaluation were: CR in 47.6%, CR + CRh + CRi in 81.0% and MLFS in 11.9% of patients (Table 1). The majority (97.1%) of responders experienced at least one cycle delay in administration of CVA post response. Conclusions: Cusatuzumab administered in combination with venetoclax and azacitidine to elderly patients with untreated AML was generally well tolerated and demonstrated a safety profile consistent with that previously reported with venetoclax-azacitidine, with the addition of generally manageable IRRs. Response rates support an additive effect of cusatuzumab to the standard of care with potential for improved clinical outcomes. However, further clinical trials are needed for validation of these initial results. HK and GB contributed equally to this publ cation. [Formula presented] Disclosures: Roboz: AstraZeneca: Consultancy;Janssen: Research Funding;Bristol Myers Squibb: Consultancy;Jasper Therapeutics: Consultancy;Agios: Consultancy;Novartis: Consultancy;Amgen: Consultancy;Blueprint Medicines: Consultancy;Janssen: Consultancy;Helsinn: Consultancy;Daiichi Sankyo: Consultancy;Glaxo SmithKline: Consultancy;Celgene: Consultancy;Jazz: Consultancy;MEI Pharma - IDMC Chair: Consultancy;Mesoblast: Consultancy;Actinium: Consultancy;AbbVie: Consultancy;Astex: Consultancy;Bayer: Consultancy;Astellas: Consultancy;Roche/Genentech: Consultancy;Pfizer: Consultancy;Otsuka: Consultancy. Aribi: Seagen: Consultancy. Brandwein: Astellas: Honoraria;Jazz: Honoraria;Amgen: Honoraria;Taiho: Honoraria;BMS/Celgene: Honoraria;Pfizer: Honoraria;Abbvie: Honoraria;University of Alberta: Current Employment. Döhner: Astellas: Consultancy, Honoraria, Research Funding;AstraZeneca: Consultancy, Honoraria;Berlin-Chemie: Consultancy, Honoraria;Amgen: Consultancy, Honoraria, Research Funding;Abbvie: Consultancy, Honoraria, Research Funding;Agios: Consultancy, Honoraria, Research Funding;Celgene: Consultancy, Honoraria, Research Funding;GEMoaB: Consultancy, Honoraria;Helsinn: Consultancy, Honoraria;Janssen: Consultancy, Honoraria;Jazz: Consultancy, Honoraria, Research Funding;Novartis: Consultancy, Honoraria, Research Funding;Oxford Biomedicals: Consultancy, Honoraria;Pfizer: Research Funding;Roche: Consultancy, Honoraria;Gilead: Consultancy, Honoraria;Bristol Myers Squibb: Consultancy, Honoraria, Research Funding;Astex: Consultancy, Honoraria;Ulm University Hospital: Current Employment. Fiedler: Jazz Pharmaceuticals: Consultancy, Other: support for meeting attendance;Abbvie: Consultancy, Honoraria;Morphosys: Consultancy;Celgene: Consultancy;Pfizer: Consultancy, Research Funding;Novartis: Consultancy;ARIAD/Incyte: Consultancy;Amgen: Consultancy, Other: support for meeting attendance, Patents & Royalties, Research Funding;Servier: Consultancy, Other: support for meeting attendance;Daiichi Sankyo: Consultancy, Other: support for meeting attendance;Stemline: Consultancy. Gandini: argenx: Current Employment, Current equity holder in publicly-traded company, Divested equity in a private or publicly-traded company in the past 24 months. Geddes: University of Calgary: Current Employment;Taiho: Consultancy, Membership on an entity's Board of Directors or advisory committees;Jazz: Consultancy, Membership on an entity's Board of Directors or advisory committees;Pfizer: Consultancy, Membership on an entity's Board of Directors or advisory committees;Novartis: Consultancy;BMS: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau;Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees;Amgen: Consultancy;Paladin: Consultancy;Janssen: Research Funding;Geron: Research Funding;Abbvie: Membership on an entity's Board of Directors or advisory committees, Research Funding. Hou: University of Pittsburgh Medical Center Hillman Cancer Centers: Current Employment;AbbVie: Honoraria;AstraZeneca: Honoraria;Karyopharm: Honoraria;Chinese American Hematology Oncology Network: Membership on an entity's Board of Directors or advisory committees. Howes: Janssen R&D, part of Johnson & Johnson: Current Employment;Johnson & Johnson: Current holder of individual stocks in a privately-held company, Current holder of stock options in a privately-held company. Hultberg: argenx: Current Employment, Patents & Royalties. Huselton: University of Rochester: Current Employment. Jacobs: Argenx BV: Current Employment, Current equity holder in publicly-traded company;University of Antwerp: Ended employment in the past 24 months. Kane: Janssen R&D, part of Johnson & Johnson: Current Employment, Current equity holder in publicly-traded company. Lech-Marańda: Takeda: Membership on an entity's Board of Directors or advisory committees;AbbVie: Membership on an entity's Board of Directors r advisory committees;Novartis: Membership on an entity's Board of Directors or advisory committees;Roche: Membership on an entity's Board of Directors or advisory committees;Janssen-Cilag: Membership on an entity's Board of Directors or advisory committees;Amgen: Membership on an entity's Board of Directors or advisory committees;Sanofi: Membership on an entity's Board of Directors or advisory committees;Gilead: Membership on an entity's Board of Directors or advisory committees, Research Funding. Louwers: argenx: Current Employment, Patents & Royalties: Patents (no royalties). Nottage: Janssen R&D, part of Johnson & Johnson: Current Employment;Johnson & Johnson: Current holder of individual stocks in a privately-held company, Current holder of stock options in a privately-held company. Platzbecker: Novartis: Honoraria;AbbVie: Honoraria;Janssen: Honoraria;Celgene/BMS: Honoraria;Geron: Honoraria;Takeda: Honoraria. Rampal: Pharmaessentia: Consultancy;BMS/Celgene: Consultancy;Abbvie: Consultancy;Sierra Oncology: Consultancy;Incyte: Consultancy, Research Funding;Blueprint: Consultancy;Disc Medicine: Consultancy;Jazz Pharmaceuticals: Consultancy;Constellation: Research Funding;Kartos: Consultancy;Stemline: Consultancy, Research Funding;CTI: Consultancy;Novartis: Consultancy;Memorial Sloan Kettering: Current Employment. Salman: Janssen: Current Employment, Current holder of individual stocks in a privately-held company, Current holder of stock options in a privately-held company. Shah: Janssen R&D, part of Johnson & Johnson: Current Employment. Stuart: Clinical Drug Development Consultants LLC: Current Employment;Argenx: Consultancy;Cleave Therapeutics: Consultancy;Triphase Accelerator Corp: Consultancy;IgM Biosciences: Consultancy;Revolution Medicines: Consultancy;Jiya Corp:Consultancy;Geron Corp: Current holder of individual stocks in a privately-held company. Subklewe: Janssen: Consultancy;Pfizer: Consultancy, Speakers Bureau;Takeda: Speakers Bureau;Klinikum der Universität München: Current Employment;MorphoSys: Research Funding;Novartis: Consultancy, Research Funding, Speakers Bureau;Roche: Research Funding;Seattle Genetics: Consultancy, Research Funding;Miltenyi: Research Funding;Gilead: Consultancy, Research Funding, Speakers Bureau;Amgen: Consultancy, Research Funding, Speakers Bureau;BMS/Celgene: Consultancy, Research Funding, Speakers Bureau. Sumbul: argenx: Current Employment. Wang: Takeda: Consultancy, Honoraria, Other: Advisory board;Jazz Pharmaceuticals: Consultancy, Honoraria, Other: Advisory Board;Astellas: Consultancy, Membership on an entity's Board of Directors or advisory committees;Stemline Therapeutics: Consultancy, Honoraria, Other: Advisory board, Speakers Bureau;AbbVie: Consultancy, Membership on an entity's Board of Directors or advisory committees;Kite Pharmaceuticals: Consultancy, Honoraria, Other: Advisory Board;GlaxoSmithKline: Consultancy, Honoraria, Other: Advisory Board;Genentech: Membership on an entity's Board of Directors or advisory committees;BMS/Celgene: Membership on an entity's Board of Directors or advisory committees;DAVA Oncology: Consultancy, Speakers Bureau;Kura Oncology: Consultancy, Honoraria, Other: Advisory board, steering committee, Speakers Bureau;Novartis: Consultancy, Honoraria, Other: Advisory Board;Mana Therapeutics: Consultancy, Honoraria;Pfizer: Consultancy, Honoraria, Other: Advisory Board, Speakers Bureau;Rafael Pharmaceuticals: Other: Data safety monitoring committee;Gilead: Consultancy, Honoraria, Other: Advisory board;Daiichi Sankyo: Consultancy, Honoraria, Other: Advisory board;PTC Therapeutics: Consultancy, Honoraria, Other: Advisory board;Genentech: Consultancy;MacroGenics: Consultancy. Wierzbowska: Jazz: Research Funding;Pfizer: Honoraria;Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees;Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees;Astellas: Honoraria, Membership on an entity's Board of Directors or advisory comm ttees;Abbvie: Honoraria, Membership on an entity's Board of Directors or advisory committees;BMS: Honoraria. Yao: Statagize LLC: Current Employment;Puma Biotechnology, Inc.: Ended employment in the past 24 months;Argenx: Consultancy. Yee: Astex: Membership on an entity's Board of Directors or advisory committees, Research Funding;Janssen: Research Funding;TaiHo: Membership on an entity's Board of Directors or advisory committees;Otsuka: Membership on an entity's Board of Directors or advisory committees;Onconova: Research Funding;Pfizer: Membership on an entity's Board of Directors or advisory committees;Tolero: Research Funding;Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding;Paladin: Membership on an entity's Board of Directors or advisory committees;MedImmune: Research Funding;AbbVie: Honoraria;Bristol-Myers Squibb/Celgene: Membership on an entity's Board of Directors or advisory committees;Shattuck Labs: Membership on an entity's Board of Directors or advisory committees;Forma Therapeutics: Research Funding;Takeda: Membership on an entity's Board of Directors or advisory committees;Geron: Research Funding;Genentech: Research Funding;F. Hoffmann La Roche: Membership on an entity's Board of Directors or advisory committees, Research Funding;Jazz: Research Funding. Kantarjian: Immunogen: Research Funding;Astra Zeneca: Honoraria;KAHR Medical Ltd: Honoraria;Astellas Health: Honoraria;Pfizer: Honoraria, Research Funding;NOVA Research: Honoraria;Ascentage: Research Funding;Precision Biosciences: Honoraria;Novartis: Honoraria, Research Funding;Aptitude Health: Honoraria;Ipsen Pharmaceuticals: Honoraria;Jazz: Research Funding;Daiichi-Sankyo: Research Funding;BMS: Research Funding;Amgen: Honoraria, Research Funding;AbbVie: Honoraria, Research Funding;Taiho Pharmaceutical Canada: Honoraria. Borthakur: Protagonist: Consultancy;Ryvu: Research Funding;Astex: Research Funding;GSK: Consultancy;Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees;Takeda: Membership on an entity's Board of Directors or advisory committees;University of Texas MD Anderson Cancer Center: Current Employment;ArgenX: Membership on an entity's Board of Directors or advisory committees.